While the COVID pandemic has thankfully been over for some time now, there is still a considerable number of people in the world (about 400 million) suffering from long COVID. Long COVID is a chronic ...

The coffee paradox in adenosine-mediated antidepressant action. Depression (left) and coffee consumption (right) are both linked through adenosine signaling (center), creating a pharmacological ...

David Zaslav wants a bidding war for Warner Bros. Discovery – and he’s looking for assistance from Donald Trump’s Justice Department to make it happen, On The Money has learned. I know it sounds crazy ...

Scientists at École Polytechnique Fédérale Lausanne (EPFL), and at UNIL-CHUV, University Hospital Lausanne (CHUV) and University of Lausanne (UNIL) have developed a computational method to create ...

Background: Notch receptor–ligand interaction is ubiquitous and fundamental for coordinating cellular differentiation and determining cell fate for the development of various tissues and organs.

The evolutionarily conserved Notch signaling pathway is essential for cell-fate determination, organogenesis, and tissue homeostasis. Notch receptors and their ligands are transmembrane proteins with ...

A striking image from Tiananmen Square has resurfaced the global north's anxieties about a shifting world order. North Korean leader Kim Jong Un stood shoulder to shoulder with Chinese President Xi ...

Rail TempEst ™, a new software application from KB Signaling Inc. (KBS), provides data that goes “beyond forecasts and assumptions toward real-time, high-resolution rail temperature and measurements ...

The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...

A new paper published today in Cell highlights how researchers have leveraged AI-based computational protein design to create a novel synthetic ligand that activates the Notch signaling pathway, a key ...