Homologous recombination DNA repair deficiency (HRD) is a therapeutic biomarker for sensitivity to platinum and poly(ADP-ribose) polymerase inhibitor therapies in breast and ovarian cancers. Several ...
A recent study, undertaken by researchers at the Tokyo Metropolitan University and the Tokyo Metropolitan Institute of Medical Science (both Japan), unravels key steps in the process of homologous ...
Homologous recombination (HR) is an important process that plays multiple crucial roles during meiosis, a type of cell cycle dedicated to sexual reproduction. During HR, homologous DNA molecules ...
CN signatures were prevalent across cancer types and associated with diverse processes including focal tandem duplications, seismic amplifications, genome-wide loss of heterozygosity (gLOH), and HRD.
Ludmil Alexandrov, PhD, on Use of AI to Predict HRD and Response Directly From Routine Biopsy Slides
A novel artificial intelligence (AI) protocol called DeepHRD was able to predict homologous recombination deficiency (HRD) in ovarian and breast cancers directly from routine histopathological slides.
Association for Molecular Pathology publishes best practice recommendations for clinical HRD testing
ROCKVILLE, Md. – June 24, 2025 – The Association for Molecular Pathology, the premier global molecular diagnostic professional society, today announced the publication of best practice recommendations ...
Professor Neil Hunter, Department of Microbiology and Molecular Genetics, has been elected as a Fellow of the Royal Society of the United Kingdom. Hunter, how is also an HHMI Investigator, studies the ...
Analysis of hundreds of single-cell genomes from Yellowstone National Park shows bacterial species are less cohesive than previously thought.
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