Insulin induced gene-2 (Insig-2) is an ER-resident protein that inhibits the activation of sterol regulatory element-binding proteins (SREBPs). However, cellular factors that regulate Insig-2 ...

Glucagon raises the blood glucose concentration by mobilizing hepatic glycogen stores through activation of liver phosphorylase. Because crystalline glucagon is rapidly inactivated once it enters the ...

Class B G protein-coupled receptors (GPCRs) exert essential action in hormonal homeostasis and are important therapeutic targets for a variety of diseases including metabolic disorders such as type 2 ...

LA JOLLA, CA -- An international team led by scientists at The Scripps Research Institute (TSRI) has determined and analyzed the three-dimensional atomic structure of the human glucagon receptor. The ...

G protein-coupled receptors (GPCRs) are essential for cell signal transduction and constitute the largest drug target protein family. Upon agonist stimulation, these receptors activate multiple ...

Scientists have determined and analyzed the three-dimensional atomic structure of the human glucagon receptor. The receptor, found mainly on liver and kidney cells, helps regulate glucose levels in ...

The γ-radiation-induced crosslinking of phenylalanine to glucagon, mediated by OH·, has been shown to involve a limited number of binding sites on the glucagon molecule. Glucagon-phenylalanine adducts ...

Scientists are exploring a central component in glucose regulation. Their findings shed new light on the structure of the glucagon receptor, a highly promising target for diabetes drug development.

Habegger is a professor in the UAB Department of Medicine Division of Endocrinology, Diabetes and Metabolism and also a scientist in the UAB Nutrition Obesity Research Center who studies how glucagon ...

Overview: Glucagon is commonly used to increase blood sugar levels in people with dangerously low levels. It can also be used during certain tests to slow down gut movement. Common side effects may ...

Class B G protein-coupled receptors (GPCRs) exert essential action in hormonal homeostasis and are important therapeutic targets for a variety of diseases including metabolic disorders such as type 2 ...